PUBLICATION LIST

Publications

  • Does old-to-young kidney transplantation rejuvenate old donor kidneys? 

    Takahashi-Kobayashi M, Kawanishi K, Usui J, Yamazaki S, Seshan SV, Yamagata K. 

    Histol Histopathol. 2024 Oct 7:18829. doi: 10.14670/HH-18-829. Online ahead of print.PMID: 39478629

  • Preexisting senescent fibroblasts in the aged bladder create a tumor-permissive niche through CXCL12 secretion. 

    Meguro S, Johmura Y, Wang TW, Kawakami S, Tanimoto S, Omori S, Okamura YT, Hoshi S, Kayama E, Yamaguchi K, Hatakeyama S, Yamazaki S, Shimizu E, Imoto S, Furukawa Y, Kojima Y, Nakanishi M.

    Nat Aging. 2024 Sep 9. doi: 10.1038/s43587-024-00704-1. Online ahead of print.PMID: 39251867

  • Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization. 

    Kaito S, Aoyama K, Oshima M, Tsuchiya A, Miyota M, Yamashita M, Koide S, Nakajima-Takagi Y, Kozuka-Hata H, Oyama M, Yogo T, Yabushita T, Ito R, Ueno M, Hirao A, Tohyama K, Li C, Kawabata KC, Yamaguchi K, Furukawa Y, Kosako H, Yoshimi A, Goyama S, Nannya Y, Ogawa S, Agger K, Helin K, Yamazaki S, Koseki H, Doki N, Harada Y, Harada H, Nishiyama A, Nakanishi M, Iwama A.  

    Nat Commun. 2024 Aug 28;15(1):7359. doi: 10.1038/s41467-024-50498-4.PMID: 39198387 

  • M2 macrophage-derived TGF-β induces age-associated loss of adipogenesis through progenitor cell senescence. 

    Zeng X, Wang TW, Yamaguchi K, Hatakeyama S, Yamazaki S, Shimizu E, Imoto S, Furukawa Y, Johmura Y, Nakanishi M.

    Mol Metab. 2024 Jun;84:101943. doi: 10.1016/j.molmet.2024.101943. Epub 2024 Apr 23.PMID: 38657734

  • Heart failure promotes multimorbidity through innate immune memory. 

    Nakayama Y, Fujiu K, Oshima T, Matsuda J, Sugita J, Matsubara TJ, Liu Y, Goto K, Kani K, Uchida R, Takeda N, Morita H, Xiao Y, Hayashi M, Maru Y, Hasumi E, Kojima T, Ishiguro S, Kijima Y, Yachie N, Yamazaki S, Yamamoto R, Kudo F, Nakanishi M, Iwama A, Fujiki R, Kaneda A, Ohara O, Nagai R, Manabe I, Komuro I. Sci Immunol. 2024 May 24;9(95):eade3814. doi: 10.1126/sciimmunol.ade3814. Epub 2024 May 24.PMID: 38787963

  • Age-related changes in the hematopoietic stem cell pool revealed via quantifying the balance of symmetric and asymmetric divisions

    Kawahigashi T, Iwanami S, Takahashi M, Bhadury J, Iwami S, Yamazaki S.

    PLoS One. 2024 Jan 29;19(1):e0292575. doi: 10.1371/journal.pone.0292575. eCollection 2024.PMID: 38285676 

  • Rejuvenated iPSC-derived GD2-directed CART Cells Harbor Robust CytotoxicityAgainst Small Cell Lung Cancer

    Kinoshita S, Ishii M, Ando J, Kimura T, Yamaguchi T, Harada S, Takahashi F, Nakashima K, Nakazawa Y, Yamazaki S, Ohshima K, Takahashi K, Nakauchi H, Ando M.
    Cancer Res Commun. 2024 Mar 11;4(3):723-737. doi: 10.1158/2767-9764.CRC-23-0259. PMID: 38380966; PMCID: PMC10926899.

  • Activated mesenchymal stem/stromal cells promote myeloid cell differentiationvia CCL2/CCR2 signaling

    Yamazaki S, Mabuchi Y, Kimura T, Suto EG, Hisamatsu D, Naraoka Y, Kondo A, Azuma Y, Kikuchi R, Nishikii H, Morishita S, Araki M, Komatsu N, Akazawa C.

    Stem Cell Reports. 2024 Mar 12;19(3):414-425. doi:10.1016/j.stemcr.2024.02.002. Epub 2024 Feb 29. PMID: 38428413; PMCID: PMC10937152.

  • A novel Kit mutant rat enables hematopoietic stem cell engraftment without irradiation

    Iida R, Ishida S, Wang J, Hattori K, Yoshimi K, Yamazaki S, Mashimo T.Iida R, Ishida S, Wang J, Hattori K, Yoshimi K, Yamazaki S, Mashimo T.

    Exp Hematol. 2024 Apr;132:104174. doi: 10.1016/j.exphem.2024.104174. Epub 2024 Feb 6.PMID: 38331018

  • Understanding genetic heterogeneity in gene-edited hematopoietic stem cell products

    Becker HJ, Yamazaki S.

    Exp Hematol. 2024 Jan;129:104133. doi: 10.1016/j.exphem.2023.11.007. Epub 2023 Nov 29.PMID: 38036097

  • Ex vivo expansion of human hematopoietic stem cells and clinical applications

    Sakurai M, Ishitsuka K, Becker HJ, Yamazaki S.

    Cancer Sci. 2024 Mar;115(3):698-705. doi: 10.1111/cas.16066. Epub 2024 Jan 14.PMID: 38221718 Free PMC article. 

  • Purging myeloma cell contaminants and simultaneous expansion of peripheral blood-mobilized stem cells

    Ishitsuka K, Nishikii H, Kimura T, Sugiyama-Finnis A, Yamazaki S.

    Exp Hematol. 2024 Mar;131:104138. doi: 10.1016/j.exphem.2023.104138. Epub 2023 Dec 25.PMID: 38151170 

  • Hyperactive Natural Killer cells in Rag2 knockout mice inhibit the development of acute myeloid leukemia

    Sugimoto E, Li J, Hayashi Y, Iida K, Asada S, Fukushima T, Tamura M, Shikata S, Zhang W, Yamamoto K, Kawabata KC, Kawase T, Saito T, Yoshida T, Yamazaki S, Kaito Y, Imai Y, Denda T, Ota Y, Fukuyama T, Tanaka Y, Enomoto Y, Kitamura T, Goyama S.

    Commun Biol. 2023 Dec 21;6(1):1294. doi: 10.1038/s42003-023-05606-3.PMID: 38129572 

  • LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits

    Li D, Johmura Y, Morimoto S, Doi M, Nakanishi K, Ozawa M, Tsunekawa Y, Inoue-Yamauchi A, Naruse H, Matsukawa T, Takeshita Y, Suzuki N, Aoki M, Nishiyama A, Zeng X, Konishi C, Suzuki N, Nishiyama A, Harris AS, Morita M, Yamaguchi K, Furukawa Y, Nakai K, Tsuji S, Yamazaki S, Yamanashi Y, Shimada S, Okada T, Okano H, Toda T, Nakanishi M.  

    Nat Aging. 2023 Aug;3(8):1001-1019. doi: 10.1038/s43587-023-00464-4. Epub 2023 Jul 20.PMID: 37474791

  • Controlling genetic heterogeneity in gene-edited hematopoietic stem cells by single-cell expansion

    Becker HJ, Ishida R, Wilkinson AC, Kimura T, Lee MSJ, Coban C, Ota Y, Tanaka Y, Roskamp M, Sano T, Tojo A, Kent DG, Yamazaki S.

    Cell Stem Cell. 2023 Jul 6;30(7):987-1000.e8. doi: 10.1016/j.stem.2023.06.002. Epub 2023 Jun 28.PMID: 37385251

  • Chemically defined cytokine-free expansion of human haematopoietic stem cells

    Sakurai M, Ishitsuka K, Ito R, Wilkinson AC, Kimura T, Mizutani E, Nishikii H, Sudo K, Becker HJ, Takemoto H, Sano T, Kataoka K, Takahashi S, Nakamura Y, Kent DG, Iwama A, Chiba S, Okamoto S, Nakauchi H, Yamazaki S.  

    Nature. 2023 Mar;615(7950):127-133. doi: 10.1038/s41586-023-05739-9. Epub 2023 Feb 22.PMID: 36813966

  • [Development of low-cost ex vivo hematopoietic stem cell expansion]

    Kimura T, Yamazaki S.
    Rinsho Ketsueki. 2022;63(10):1422-1429. doi: 10.11406/rinketsu.63.1422.PMID: 36351651 Japanese.

  • Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes.

    Wang TW, Johmura Y, Suzuki N, Omori S, Migita T, Yamaguchi K, Hatakeyama S, Yamazaki S, Shimizu E, Imoto S, Furukawa Y, Yoshimura A, Nakanishi M.  

    Nature. 2022 Nov;611(7935):358-364. doi: 10.1038/s41586-022-05388-4. Epub 2022 Nov 2.PMID: 36323784

  • Identification and characterization of in vitro expanded hematopoietic stem cells

    Che JLC, Bode D, Kucinski I, Cull AH, Bain F, Becker HJ, Jassinskaja M, Barile M, Boyd G, Belmonte M, Zeng AGX, Igarashi KJ, Rubio-Lara J, Shepherd MS, Clay A, Dick JE, Wilkinson AC, Nakauchi H, Yamazaki S, Göttgens B, Kent DG.

    EMBO Rep. 2022 Aug 16:e55502. doi: 10.15252/embr.202255502. PMID: 35971894

  • Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

    Itokawa N, Oshima M, Koide S, Takayama N, Kuribayashi W, Nakajima-Takagi Y, Aoyama K, Yamazaki S, Yamaguchi K, Furukawa Y, Eto K, Iwama A.  

    Nat Commun. 2022 May 16;13(1):2691. doi: 10.1038/s41467-022-30440-2.PMID: 35577813 

  • Hematopoietic progenitor cells specifically induce a unique immune response in dental pulp under conditions of systemic inflammation

    Osaki J, Yamazaki S, Hikita A, Hoshi K.

    Heliyon. 2022 Feb 5;8(2):e08904. doi: 10.1016/j.heliyon.2022.e08904. eCollection 2022 Feb.PMID: 35198771 

  • Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma

    Harada S, Ando M, Ando J, Ishii M, Yamaguchi T, Yamazaki S, Toyota T, Ohara K, Ohtaka M, Nakanishi M, Shin C, Ota Y, Nakashima K, Ohshima K, Imai C, Nakazawa Y, Nakauchi H, Komatsu N

    Mol Ther. 2022 Feb 2;30(2):534-549. doi: 10.1016/j.ymthe.2021.10.006. Epub 2021 Oct 8.PMID: 34628050

  • Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma. 

    Harada S, Ando M, Ando J, Ishii M, Yamaguchi T, Yamazaki S, Toyota T, Ohara K, Ohtaka M, Nakanishi M, Shin C, Ota Y, Nakashima K, Ohshima K, Imai C, Nakazawa Y, Nakauchi H, Komatsu N.

    Mol Ther. 2022 Feb 2;30(2):534-549. doi: 10.1016/j.ymthe.2021.10.006. Epub 2021 Oct 8.PMID: 34628050

  • Immunohistological score of transcription factor 21 had a positive correlation with its urinary excretion and proteinuria in immunoglobulin A nephropathy.

    Takahashi-Kobayashi M, Usui J, Yaguchi M, Yamazaki S, Kawamura T, Kaneko S, Seshan SV, Yamagata K.

    Histol Histopathol. 2021 Oct;36(10):1093-1098. doi: 10.14670/HH-18-367. Epub 2021 Jul 29.PMID: 34323285

  • Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo. 

    Sudo K, Yamazaki S, Wilkinson AC, Nakauchi H, Nakamura Y. 

    Stem Cell Res. 2021 Oct;56:102531. doi: 10.1016/j.scr.2021.102531. Epub 2021 Sep 3.PMID: 34509158 

  • iPSC-derived neoantigen-specific cytotoxic T-lymphocyte therapy for Ewing sarcoma. 

    Ishii M, Ando J, Yamazaki S, Toyota T, Ohara K, Furukawa Y, Suehara Y, Nakanishi M, Nakashima K, Ohshima K, Nakauchi H, Ando M.

    Cancer Immunol Res. 2021 Oct;9(10):1175-1186. doi: 10.1158/2326-6066.CIR-21-0193. Epub 2021 Aug 12.PMID: 34385178

  • Non-conditioned bone marrow chimeric mouse generation using culture-based enrichment of hematopoietic stem and progenitor cells.

    Ochi K, Morita M, Wilkinson AC, Iwama A, Yamazaki S. 

    Nat Commun. 2021 Jun 11;12(1):3568. doi: 10.1038/s41467-021-23763-z.PMID: 34117255 

  • Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche. 

    Kuribayashi W, Oshima M, Itokawa N, Koide S, Nakajima-Takagi Y, Yamashita M, Yamazaki S, Rahmutulla B, Miura F, Ito T, Kaneda A, Iwama A.

    J Exp Med. 2021 Mar 1;218(3):e20192283. doi: 10.1084/jem.20192283.PMID: 33231616

  • DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes.

    Kayamori K, Nagai Y, Zhong C, Kaito S, Shinoda D, Koide S, Kuribayashi W, Oshima M, Nakajima-Takagi Y, Yamashita M, Mimura N, Becker HJ, Izawa K, Yamazaki S, Iwano S, Miyawaki A, Ito R, Tohyama K, Lennox W, Sheedy J, Weetall M, Sakaida E, Yokote K, Iwama A. 

    Blood Adv. 2021 Jan 26;5(2):438-450. doi: 10.1182/bloodadvances.2020001461.PMID: 33496740 

  • Efficacy of the Novel Tubulin Polymerization Inhibitor PTC-028 for Myelodysplastic Syndrome 

    Zhong C, Kayamori K, Koide S, Shinoda D, Oshima M, Nakajima-Takagi Y, Nagai Y, Mimura N, Sakaida E, Yamazaki S, Iwano S, Miyawaki A, Ito R, Tohyama K, Yamaguchi K, Furukawa Y, Lennox W, Sheedy J, Weetall M, Iwama A. 

    Cancer Sci. 2020 Dec;111(12):4336-4347. doi: 10.1111/cas.14684. Epub 2020 Nov 2.PMID: 33037737 

  • The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages.

    Sato R, Reuter T, Hiranuma R, Shibata T, Fukui R, Motoi Y, Murakami Y, Tsukamoto H, Yamazaki S, Liu K, Saitoh SI, Latz E, Miyake K. 

    Int Immunol. 2020 Nov 23;32(12):785-798. doi: 10.1093/intimm/dxaa055.PMID: 32840578

  • Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo.

    Omori S, Wang TW, Johmura Y, Kanai T, Nakano Y, Kido T, Susaki EA, Nakajima T, Shichino S, Ueha S, Ozawa M, Yokote K, Kumamoto S, Nishiyama A, Sakamoto T, Yamaguchi K, Hatakeyama S, Shimizu E, Katayama K, Yamada Y, Yamazaki S, Iwasaki K, Miyoshi C, Funato H, Yanagisawa M, Ueno H, Imoto S, Furukawa Y, Yoshida N, Matsushima K, Ueda HR, Miyajima A, Nakanishi M.

    Cell Metab. 2020 Nov 3;32(5):814-828.e6. doi: 10.1016/j.cmet.2020.09.006. Epub 2020 Sep 18.PMID: 32949498 

  • Activated HoxB4-induced Hematopoietic Stem Cells from Murine Pluripotent Stem Cells via Long-Term Programming.

    Izawa K, Yamazaki S, Becker HJ, Bhadury J, Kakegawa T, Sakaguchi M, Tojo A. 

    Exp Hematol. 2020 Sep;89:68-79.e7. doi: 10.1016/j.exphem.2020.08.003. Epub 2020 Aug 12.PMID: 32795499 

  • Transcription factor 21 expression in injured podocytes of glomerular diseases. 

    Usui J, Yaguchi M, Yamazaki S, Takahashi-Kobayashi M, Kawamura T, Kaneko S, Seshan SV, Ronco P, Yamagata K.

    Sci Rep. 2020 Jul 13;10(1):11516. doi: 10.1038/s41598-020-68422-3.PMID: 32661376

  • In vivo expansion of functional human hematopoietic stem progenitor cells by butyzamide. 

    Sakurai M, Takemoto H, Mori T, Okamoto S, Yamazaki S. 

    Int J Hematol. 2020 May;111(5):739-741. doi: 10.1007/s12185-020-02849-2. Epub 2020 Mar 12.PMID: 32162097

  • Long-term eradication of extranodal NK/T cell lymphoma, nasal type, by induced pluripotent stem cell-derived Epstein-Barr virus-specific rejuvenated T cells in vivo.

    Ando M, Ando J, Yamazaki S, Ishii M, Sakiyama Y, Harada S, Honda T, Yamaguchi T, Nojima M, Ohshima K, Nakauchi H, Komatsu N. 

    Haematologica. 2020 Mar;105(3):796-807. doi: 10.3324/haematol.2019.223511. Epub 2019 Jul 11.PMID: 31296577 

  • Long-term ex vivo expansion of mouse hematopoietic stem cells.

    Wilkinson AC, Ishida R, Nakauchi H, Yamazaki S.

    Nat Protoc. 2020 Feb;15(2):628-648. doi: 10.1038/s41596-019-0263-2. Epub 2020 Jan 8.PMID: 31915389 

  • Use of polyvinyl alcohol for chimeric antigen receptor T-cell expansion.

    Nishimura T, Hsu I, Martinez-Krams DC, Nakauchi Y, Majeti R, Yamazaki S, Nakauchi H, Wilkinson AC.

    Exp Hematol. 2019 Dec;80:16-20. doi: 10.1016/j.exphem.2019.11.007. Epub 2019 Dec 23.PMID:31874780

  • Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma.

    Rizk M, Rizq O, Oshima M, Nakajima-Takagi Y, Koide S, Saraya A, Isshiki Y, Chiba T, Yamazaki S, Ma A, Jin J, Iwama A, Mimura N. 

    Cancer Sci. 2019 Dec;110(12):3695-3707. 

  • Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia.

    Hayashi Y, Goyama S, Liu X, Tamura M, Asada S, Tanaka Y, Fukuyama T, Wunderlich M, O’Brien E, Mizukawa B, Yamazaki S, Matsumoto A, Yamasaki S, Shibata T, Matsuda K, Sashida G, Takizawa H, Kitamura T. 

    Nat Commun. 2019 Oct 25;10(1):4869.

  • Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche.

    Kato Y, Hou LB, Miyagi S, Nitta E, Aoyama K, Shinoda D, Yamazaki S, Kuribayashi W, Isshiki Y, Koide S, Si S, Saraya A, Matsuzaki Y, van Lohuizen M, Iwama A.

    Exp Hematol. 2019 Aug;76:24-37. Epub 2019 Aug 11.

  • Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned 　transplantation.

    Wilkinson AC, Ishida R, Kikuchi M, Sudo K, Morita M, Crisostomo RV, Yamamoto R, Loh KM, Nakamura Y, Watanabe M, Nakauchi H, Yamazaki S.

     Nature. 2019. doi: 10.1038/s41586-019-1244. 

  • Long-term eradication of extranodal NK/T cell lymphoma, nasal type, by induced pluripotent stem cell-derived Epstein-Barr virus-specific rejuvenated T cells in vivo.

    Ando M, Ando J, Yamazaki S, Ishii M, Sakiyama Y, Harada S, Honda T, Yamaguchi T, Nojima M, Ohshima K, Nakauchi H, Komatsu N.

    Haematologica. 2019 Jul 11. pii: haematol.2019.223511.2019.223511

  • Mesenchymal-Epithelial Interactome Analysis Reveals Essential Factors Required for Fibroblast-Free Alveolosphere Formation.

    Shiraishi K, Shichino S, Ueha S, Nakajima T, Hashimoto S, Yamazaki S, Matsushima K.

    iScience. 2019 Jan 25;11:318-333.

  • Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation. 

    Hamanaka S, Umino A, Sato H, Hayama T, Yanagida A, Mizuno N, Kobayashi T, Kasai M, Suchy FP, Yamazaki S, Masaki H, Yamaguchi T, Nakauchi H.

    Stem Cell Reports. 2018 Oct 9;11(4):988-997.

  • Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.

    Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T.

    Nat Commun. 2018 Jul 16;9(1):2733. 

  • Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress. 

    Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi H, Hirao A. 

    Cell Stem Cell. 2018 May 3;22(5):713-725.e8. 

  • Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells.

    Si S, Nakajima-Takagi Y, Iga T, Tsuji M, Hou L, Oshima M, Koide S, Saraya A, Yamazaki S, Takubo K, Kubota Y, Minamino T, Iwama A. 

    Exp Hematol. 2018 Apr 27. pii: S0301-472X(18)30213-3.

  • Branched-chain amino acid depletion conditions bone marrow for hematopoietic stem cell transplantation avoiding amino acid imbalance-associated toxicity. 

    Wilkinson AC, Morita M, Nakauchi H, Yamazaki S. 

    Exp Hematol. 2018 Apr 26. S0301-472 (18)30173-5. 

  • Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice. 

    Kon A, Yamazaki S, Nannya Y, Kataoka K, Ota Y, Nakagawa MM, Yoshida K, Shiozawa Y, Morita M, Yoshizato T, Sanada M, Nakayama M, Koseki H, Nakauchi H, Ogawa S. 

    Blood. 2018 Feb 8;131(6):621-635. 

  • In Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma. 

    Tsukada M, Ota Y, Wilkinson AC, Becker HJ, Osato M, Nakauchi H, Yamazaki S.

    Stem Cell Reports. 2017 Oct 10;9(4):1024-1033. 

  • An All-Recombinant Protein-Based Culture System Specifically Identifies Hematopoietic Stem Cell Maintenance Factors. 

    Ieyasu A, Ishida R, Kimura T, Morita M, Wilkinson AC, Sudo K, Nishimura T, Ohehara J, Tajima Y, Lai CY, Otsu M, Nakamura Y, Ema H, Nakauchi H,Yamazaki S.

     Stem Cell Reports. 2017 Mar 14 ;8(3):500-508.

  • Continuous cell supply from Krt7-expressing hematopoietic stem cells during native hematopoiesis revealed by targeted in vivo gene transfer method.

    Tajima Y, Ito K, Umino A, Wilkinson AC, Nakauchi H, Yamazaki S.

    Sci Rep. 2017 Jan 18 ;7:40684.

  • Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation.

    Taya Y, Ota Y, Wilkinson AC, Kanazawa A, Watarai H, Kasai M, Nakauchi H and Yamazaki S.

    Science. Oct 20, 2016 354(6316):1152-1155.

  • Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenyous perivascular niche. 

    Chen JY, Miyanishi M, Wang SK, Yamazaki S, Shnha R, Kao KS, Seita J, Sahoo D, Nakauchi H, Weissman IL.

    Nature. 2016 Feb 11;530(7589):223-7.

  • A Safeguard System for Induced Pluripotent Stem Cell Derived Rejuvenated T Cell Therapy.

    Ando M, Nishimura T, Yamazaki S, Yamaguchi T, Kawana-Tachikawa A, Hayama T, Nakauchi Y, Ando J, Ota Y, Takahashi S, Nishimura K, Ohtaka M, Nakanishi M, Miles JJ, Burrows SR, Brenner MK, Nakauchi H. 

    Stem Cell Reports. 2015 Oct 13;5(4): 597-608.

  • Reactive oxygen species in hematopoietic stem cells affect culture outcome under inflammatory conditions. 

    Ishida T, Yamazaki S, Nakauchi H, Higashihara M, Otsu M. 

    Open Journal of Hematology. 2015;6:6-7.

  • Effective treatment against severe Graft-versus-Host Disease with allele-specific anti-HLA monoclonal antibody in a humanized-mouse model. 

    Nakauchi Y, Yamazaki S, Napier C S, Usui J, Ota Y, Takahashi S, Watanabe N, Nakauchi H. 

    Exp Hematol. 2015 Feb;43(2):79-88.

  • Impaired hematopoietic differentiation of RUNX1 mutated induced pluripotent stem cells derived from FPD/AML patients.

    Sakurai M, Kunimoto H, Watanabe N, Fukuchi Y, Yuasa S, Yamazaki S, Nishimura T, Sadahira K, Fukuda K, Okano H, Nakauchi H, Morita Y, Matsumura I, Kudo K, Ito E, Ebihara Y, Tsuji K, Harada Y, Harada H, Okamoto S, Nakajima H.

    Leukemia. 2014 Dec:28(12):2344-54.

  • Generation of recombination activating gene-1-deficient neonatal piglets: a model of T and B cell deficient severe combined immune deficiency.

    Ito T, Sendai Y, Yamazaki S, Seki-Soma M, Hirose K, Watanabe M, Fukawa K, Nakauchi H. 

    PLoS One. 2014 Dec 1;9(12):e113833.

  • A melanocyte-melanoma precursor niche in sweat glands of volar skin.

    Okamoto N, Aoto T, Uhara H, Yamazaki S, Akutsu H, Umezawa A, Nakauchi H, Miyachi Y, Saida T, Nishimura EK.

    Pigment Cell Melanoma. 2014 Nov;27(6):1039-50.

  • Gene Targeting Study Reveals Unexpected Expression of Brain Expressed X-linked 2 in Endocrine and Tissue Stem/projenitor Cells in Mice.

    Ito K, Yamazaki S, Yamamoto R, Tajima Y, Yanagida A, Kobayashi T, Kato-Itoh M, Kakuta S, Iwakura Y, Nakauchi H, Kamiya A. 

     J Biol Chem. 2014 Oct 24;289(43):29892-911.

  • Generation of Mouse Functional Oocytes in Rat by Xeno-Ectopic Transplantation of Primorial Germ Cells.

    Hayama T, Yamaguchi T, Kato-Itoh M, Hamanaka S, Kawarai M, Sanbo M, Tamura C, Lee YS, Yanagida A, Murayama H, Mizuno N, Umino A, Sato H, Yamazaki S, Masaki H, Kobayashi T, Hirabayashi M, Nakauchi H. 

    Biol Reprod. 2014 Oct;91(4):89.

  • Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies. 

    Kazuki Y, Yakura Y, Abe S, Osaki M, Kajitani N, Kazuki K, Takehara S, Honma K, Suemori H, Yamazaki S, Sakuma T, Toki T, Shimisu R, Nakauchi H, Yamamoto T, Oshimura M. 

    Sci Rep. 2014 Aug 27;4: 6136.

  • Stage-specific roles for Cxcr4 signaling in murine hematopoietic stem/progenitor cells in the process of bone marrow repopulation. 

    Lai CY, Yamazaki S, Okabe M, Suzuki S, Maeyama Y, Iimura Y, Onodera M, Kakuta S, Iwakura Y, Nojima M, Otsu M, Nakauchi H. 

    Stem cells. 2014 Jul;32(7):1929-42. 

  • Clock gene Bmal1 is dispensable for intrinsic properties of murine hematopoietic stem cells. 

    Ieyasu A, Tajima Y, Shimba S, Nakauchi H, Yamazaki S

    J Negat Biomed. 2014 Mar 8;13: 4.

  • The TIF1beta-HP1 System Maintains Transcriptional Integrity of Hematopoietic Stem Cells.

    Miyagi S, Koide S, Saraya A, Wendt GR, Oshima M, Konuma T, Yamazaki S, Mochizuki-Kashio M, Nakajima-Takagi Y, Wang C, Chiba T, Kitabayashi I, Nakauchi H, Iwama A. 

    Stem Cell Reports. 2014 Jan 23;2(2):145-52.

  • Immortalization of erythroblast by c-Myc and Bcl-xl enables large-scale erythrocyte production from human pluripotent stem cells.

    Hirose S, Takayama N, Nakamura S, Nagasawa K, Ochi K, Hirata S, Yamazaki S, Yamaguchi T, Otsu M, Sano S, Takahashi N, Sawaguchi A, Ito M, Kato T, Nakauchi H, Eto K.

    Stem Cell Reports. 2013 Dec 5;1(6):499-508.

  • Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation. 

    Suzuki N, Yamazaki S, Yamaguchi T, Okabe M, Masaki H, Takaki S, Otsu M and Nakauchi H.

    Mol Ther. 2013 Jul;21(7): 1424-31.

  • Development of an all in one inducible lentiviral vector for gene specific analysis of reprogramming. 

    Yamaguchi T, Hamanaka S, Kamiya A, Okabe M, Kawarai M, Wakiyama Y, Umino A, Hayama T, Sato H, Lee YS, Kato-Itoh M, Kobayashi T, Yamazaki S and Nakauchi H. 

    PLoS One. 2012;7(7): e41007.

  • Bmi-1 confers resistance to oxidative stress on hematopoietic stem cells.

    Nakamura S, Oshima M, Yuan J, Saraya A, Miyagi S, Konuma T, Yamazaki S, Osawa M, Nakauchi H, Koseki H and Iwama A.

     PLoS One. 2012 May;7(5):e36209.

  • Lethal myelofibrosis induced by Bmi-1 deficient hematopoietic stem cells unveils a tumor suppressor function of the polycomb group genes. 

    Oguro H, Yuan J, Tanaka S, Miyagi S, Mochizuki-Kashio M, Ichikawa H, Yamazaki S, Koseki H, Nakauchi H and Iwama A.

    J Exp Med. 2012 Mar 12;209(3):445-454.

  • Homeostasis of hematopoietic stem cells regulated by the myeloproliferative disease associated-gene product Lnk/Sh2b3 via Bcl-xl.

    Suzuki N, Yamazaki S, Ema H, Yamaguchi T, Nakauchi H, and Nakauchi H.

    Exp Hematol. 2012 Feb;40, 166-174.

  • Non-myelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche.

    Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, and Nakauchi H.

    Cell. 2011 Nov 23;147(5) 1146-1158.

  • Generation of germline-competent rat induced pluripotent stem cells. 

    Hamanaka S, Yamaguchi T, Kobayashi T, Kato-Itoh M, Yamazaki S, Sato H, Umino A, Wakiyama Y, Arai M, Sanbo M, Hirabayashi M, Nakauchi H. 

    PLoS One. 2011 Jul 15;6(7):e22008.

  • Hair follicle stem cells provide a functional niche for melanocyte stem cells.

    Tanimura S, Tadokoro Y, Inomata K, Binh NT, Nishie W, Yamazaki S, Nakauchi H, Tanaka Y, McMillan JR, Sawamura D, Yancey K, Shimizu H, Nishimura EK.

    Cell Stem Cell. 2011 Feb 4;8(2):177-87.

  • Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma. 

    Nakahata S, Yamazaki S, Nakauchi H, Morishita K.

    Oncogene. 2010 Jul 22;29(29):4157-69.

  • TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.

    Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T.

    J Exp Med. 2010 Jul 5;207(7): 1501-11.

  • Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.

    Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K. 

    J Clin Invest. 2010 Jun;120(1):179-90.

  • Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1.

    Oguro H, Yuan J, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H, Nakauchi H, Iwama A. 

    Cell Stem Cell. 2010 Mar 5;6(3):279-86.

  • Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.

    Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S.

    Nature. 2009 Aug 13;460(7257):904-8.

  • A rapid and efficient strategy to generate allele-specific anti-HLA monoclonal antibodies.

    Yamazaki S, Suzuki N, Saito T, Ishii Y, Takiguchi M, Nakauchi H, Watanabe N.

     J Immunol Methods. 2009 Mar 31;343(1):56-60.

  • TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation.

    Yamazaki S, Iwama A, Takayanagi S, Eto K, Ema H, Nakauchi H.

    Blood. 2009 Feb 5;113(6):1250-6.

  • Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.

    Yamanishi Y, Kitaura J, Izawa K, Matsuoka T, Oki T, Lu Y, Shibata F, Yamazaki S, Kumagai H, Nakajima H, Maeda-Yamamoto M, Tybulewicz VL, Takai T, Kitamura T. 

    Blood. 2008 Jan 15;111(2):688-98.

  • Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

    Miyamoto K, Araki KY, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, Hirao A.

    Cell Stem Cell. 2007 Jun 7;1(1):101-12.

  • Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.

    Seita J, Ema H, Ooehara J, Yamazaki S, Tadokoro Y, Yamasaki A, Eto K, Takaki S, Takatsu K, Nakauchi H.

    Proc Natl Acad Sci U S A. 2007 Feb 13;104(7): 2349-54.

  • Non-side-population hematopoietic stem cells in mouse bone marrow.

    Morita Y, Ema H, Yamazaki S, Nakauchi H. 

    Blood. 2006 Oct 15;108(8):2850-6.

  • Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells.

    Yamazaki S, Iwama A, Takayanagi S, Morita Y, Eto K, Ema H, Nakauchi H. 

    EMBO J. 2006 Aug 9;25(15):3515-23.

  • Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain.

    Takayanagi S, Hiroyama T, Yamazaki S, Nakajima T, Morita Y, Usui J, Eto K, Motohashi T, Shiomi K, Keino-Masu K, Masu M, Oike Y, Mori S, Yoshida N, Iwama A, Nakauchi H.

    Blood. 2006 Jun 1;107(11):4317-25, 2006.

  • Adult mouse hematopoietic stem cells: purification and single-cell assays.

    Ema H, Morita Y, Yamazaki S, Matsubara A, Seita J, Tadokoro Y, Kondo H, Takano H, Nakauchi H.

    Nat Protoc. 2006;1(6): 2979-87.

  • Identification of immature podocyte specific antigen using retrovirus-mediated gene transfer and cell sorting.

    Usui J, Osawa M, Yamazaki S, Morita Y, Koyama A, Nakauchi H. 

    Clin Exp Nephrol. 2005 Dec;9(4):292-6.

  • Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development.

    Matsubara A, Iwama A, Yamazaki S, Furuta C, Hirasawa R, Morita Y, Osawa M, Motohashi T, Eto K, Ema H, Kitamura T, Vestweber D, Nakauchi H.

    J Exp Med. 2005 Dec 5;202(11):483-92.

  • Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112).

    Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A.

    Int Immunol. 2004 Apr;16(4):533-8.

  • Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation.

    Yotsumoto K, Okoshi Y, Shibuya K, Yamazaki S, Tahara-Hanaoka S, Honda S, Osawa M, Kuroiwa A, Matsuda Y, Tenen DG, Iwama A, Nakauchi H, Shibuya A. 

    J Exp Med. 2003 Jul 21;198(2):223-33.