# Division of Cell Regulation


## Posts

- [AWARD](https://dcr-imsut.com/index.php/2026/02/21/749/): Dr. Takahashi received the CKD Frontier Award at the The 15th CKD Frontier Meeting
- [2026](https://dcr-imsut.com/index.php/2026/02/18/2026/)
- [Award](https://dcr-imsut.com/index.php/2026/02/17/award/): Dr. Takahashi received the Best Presentation Award at the 1st Annual Meeting of the Japan Disease Stem Cell Society.
- [A scalable two-step genome editing strategy for generating full-length gene-humanized mice at diverse genomic loci.](https://dcr-imsut.com/index.php/2026/01/14/a-scalable-two-step-genome-editing-strategy-for-generating-full-length-gene-humanized-mice-at-diverse-genomic-loci/): Taguchi J, Kikuchi M, Jeon H, Shimizu R, Mori H, Ikawa M, Yamada Y, Sato K, Ikeda T, Yamazaki S, Ozawa M.   Nat Commun. 2026 Jan 14;17(1):356. doi:10.1038/s41467-025-67900-4.PMID: 41535270
- [2025](https://dcr-imsut.com/index.php/2025/12/26/2025/)
- [Low-input proteomics identifies vWF as a negative regulator of Tet2 mutant hematopoietic stem cell expansion](https://dcr-imsut.com/index.php/2025/12/24/low-input-proteomics-identifies-vwf-as-a-negative-regulator-of-tet2-mutant-hematopoietic-stem-cell-expansion/): Jassinskaja M, Bode D, Gonka M, Roumeliotis TI, Hogg AJ, Rubio Lara JA, Bennett E, Milek J, Elberfeld S, Theeuwes B, Vijayabaskar MS, Cosme LC, Chi Che JL, MacDonald S, Ahmed S, Hall BA, Vasey G, Kooi H, Belmonte M, Shepherd MS, Brackenbury WJ, Kucinski I, Yamazaki S, Holding AN, Cull AH, Wilson NK, Göttgens B, […]
- [Prospective isolation of mouse and human hematopoietic stem cells using PLXDC2](https://dcr-imsut.com/index.php/2025/12/10/prospective-isolation-of-mouse-and-human-hematopoietic-stem-cells-using-plxdc2/): Tanaka Y, Kubota Y, Kikuchi R, Yabushita T, Kimura T, Lieberam I, Barlow JL, Bramley JW, Fukushima T, Sakuma C, Shibata T, Nakagawa M, Kurosawa Y, Maruyama T, Okumura CJ, Arima Y, Sato Y, Ono Y, Akuta T, Mizuno H, Kent DG, Jessell TM, Goyama S, Nishikii H, Kimura S, Yamazaki S, Suda T, Kitamura T […]
- [NEW PAPER WAS PUBLISHED!](https://dcr-imsut.com/index.php/2025/12/10/new-paper-was-published-6/): Dr. Tanaka’s paper has been published in Commun Biol
- [Tumor necrosis factor from leukemic environment stimulates hematopoietic stem/progenitor cells toward megakaryocyte/myeloid lineage bias](https://dcr-imsut.com/index.php/2025/12/04/tumor-necrosis-factor-from-leukemic-environment-stimulates-hematopoietic-stem-progenitor-cells-toward-megakaryocyte-myeloid-lineage-bias/): Nishikii H, Kikuchi R, Kimura T, Saito M, Kiyoki Y, Tanaka S, Sasaki Y, Kato T, Sakamoto T, Sakata-Yanagimoto M, Obara N, Yamazaki S, Chiba S. Exp Hematol. 2025 Dec 4:105332. doi: 10.1016/j.exphem.2025.105332. Online ahead of print.PMID: 41352655
- [NEW PAPER WAS PUBLISHED!](https://dcr-imsut.com/index.php/2025/09/18/new-paper-was-published-5/): Dr. Yogo’s paper has been published in STAR Protoc
- [Protocol for noninvasive imaging of hematopoietic reconstitution in live mice using Akaluc bioluminescence.](https://dcr-imsut.com/index.php/2025/09/18/protocol-for-noninvasive-imaging-of-hematopoietic-reconstitution-in-live-mice-using-akaluc-bioluminescence/): Yogo T, Yamazaki S. STAR Protoc. 2025 Sep 10;6(3):104072. doi: 10.1016/j.xpro.2025.104072. Online ahead of print.PMID: 40934075
- [Press Release](https://dcr-imsut.com/index.php/2025/07/17/press-release-2/): 造血幹細胞の”時間的ふるまい”から未来の能力を予測 ――再生医療・遺伝子治療の安全性向上へ貢献―― https://www.ims.u-tokyo.ac.jp/imsut/jp/about/press/page_00342.html https://www.ims.u-tokyo.ac.jp/imsut/content/000011378.pdf
- [NEW PAPER WAS PUBLISHED!](https://dcr-imsut.com/index.php/2025/07/17/new-paper-was-published-4/): Dr. Yogo’s paper has been published in  Nature communications
- [New Review Published!](https://dcr-imsut.com/index.php/2025/07/17/new-review-published-2/): Dr. Finnis’s review has been published in Regenerative Therapy
- [Quantitative phase imaging with temporal kinetics predicts hematopoietic stem cell diversity](https://dcr-imsut.com/index.php/2025/07/14/quantitative-phase-imaging-with-temporal-kinetics-predicts-hematopoietic-stem-cell-diversity/): Yogo T, Iwamoto Y, Becker HJ, Kimura T, Ishida R, Sugiyama-Finnis A, Yokomizo T, Suda T, Ota S, Yamazaki S. Nat Commun. 2025 Jul 14;16(1):6496. doi: 10.1038/s41467-025-61846-3.PMID: 40659629
- [NEW PAPER WAS PUBLISHED!](https://dcr-imsut.com/index.php/2025/04/10/new-paper-was-published-2/): Dr. Fukushima’s paper has been published in bioRxiv
- [Signaling networks in cancer stromal senescent cells establish malignant microenvironment](https://dcr-imsut.com/index.php/2025/04/01/signaling-networks-in-cancer-stromal-senescent-cells-establish-malignant-microenvironment/): Zhang Y, Wang TW, Tamatani M, Zeng X, Nakamura L, Omori S, Yamaguchi K, Hatakeyama S, Shimizu E, Yamazaki S, Furukawa Y, Imoto S, Johmura Y, Nakanishi M Proc Natl Acad Sci U S A. 2025 Apr 8;122(14):e2412818122. doi: 10.1073/pnas.2412818122. Epub 2025 Apr 1.PMID: 40168129
- [NEW PAPER WAS PUBLISHED!](https://dcr-imsut.com/index.php/2025/03/28/new-paper-was-published-3/): Dr. Kawano’s paper has been published in Blood
- [Hematopoietic stem cells undergo bidirectional fate transitions in vivoShare ](https://dcr-imsut.com/index.php/2025/02/25/hematopoietic-stem-cells-undergo-bidirectional-fate-transitions-in-vivoshare/): Fukushima T, Kristiansen TA, Wong LP, Keyes S, Tanaka Y, Mazzola M, Zhao T, He L, Yagi M, Hochedlinger K, Yamazaki S, Sadreyev RI, Scadden DT. bioRxiv [Preprint]. 2025 Feb 26:2025.02.23.639689. doi: 10.1101/2025.02.23.639689.PMID: 40027782
- [Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation](https://dcr-imsut.com/index.php/2025/01/28/progenitor-effect-in-the-spleen-drives-early-recovery-via-universal-hematopoietic-cell-inflation/): Yogo T, Becker HJ, Kimura T, Iwano S, Kuchimaru T, Miyawaki A, Yokomizo T, Suda T, Iwama A, Yamazaki S. Cell Rep. 2025 Jan 25;44(2):115241. doi: 10.1016/j.celrep.2025.115241. Online ahead of print.PMID: 39864058 
- [Press Release](https://dcr-imsut.com/index.php/2025/01/28/press-release/): 造血幹細胞移植後の血液再生過程を可視化し、血球回復を促進する新技術を開発 ――ユニバーサル造血前駆細胞による安全な骨髄移植―― https://www.ims.u-tokyo.ac.jp/imsut/content/000010671.pdf
- [NEW PAPER WAS PUBLISHED!](https://dcr-imsut.com/index.php/2025/01/28/dr-yogos-paper-has-been-published-in-cell-reports/): Dr. Yogo’s paper has been published in Cell Reports
- [IL-1R1 and IL-18 Signals Regulate Mesenchymal Stromal Cells in an Aged Murine Model of Myelodysplastic Syndromes.](https://dcr-imsut.com/index.php/2025/01/22/il-1r1-and-il-18-signals-regulate-mesenchymal-stromal-cells-in-an-aged-murine-model-of-myelodysplastic-syndromes/): Kawano Y, Kawano H, LaMere MW, LaMere EA, Byun DK, McGrath K, Palis J, Bajaj J, Liesveld JL, Katayama Y, Yamazaki S, Kapur R, Calvi LM, Ho TC, Becker MW.  Blood. 2025 Jan 22:blood.2024024818. doi: 10.1182/blood.2024024818. Online ahead of print.PMID: 39841001
- [2024](https://dcr-imsut.com/index.php/2024/12/31/2024/)
- [New Paper was Published!](https://dcr-imsut.com/index.php/2024/10/07/new-paper-was-published/): Dr. Takahashi’s paper was published in Histol Histopathol.
- [Does old-to-young kidney transplantation rejuvenate old donor kidneys? ](https://dcr-imsut.com/index.php/2024/10/07/does-old-to-young-kidney-transplantation-rejuvenate-old-donor-kidneys/): Takahashi-Kobayashi M, Kawanishi K, Usui J, Yamazaki S, Seshan SV, Yamagata K.  Histol Histopathol. 2024 Oct 7:18829. doi: 10.14670/HH-18-829. Online ahead of print.PMID: 39478629
- [Preexisting senescent fibroblasts in the aged bladder create a tumor-permissive niche through CXCL12 secretion. ](https://dcr-imsut.com/index.php/2024/09/09/preexisting-senescent-fibroblasts-in-the-aged-bladder-create-a-tumor-permissive-niche-through-cxcl12-secretion/): Meguro S, Johmura Y, Wang TW, Kawakami S, Tanimoto S, Omori S, Okamura YT, Hoshi S, Kayama E, Yamaguchi K, Hatakeyama S, Yamazaki S, Shimizu E, Imoto S, Furukawa Y, Kojima Y, Nakanishi M. Nat Aging. 2024 Sep 9. doi: 10.1038/s43587-024-00704-1. Online ahead of print.PMID: 39251867
- [Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization. ](https://dcr-imsut.com/index.php/2024/08/28/inhibition-of-topors-ubiquitin-ligase-augments-the-efficacy-of-dna-hypomethylating-agents-through-dnmt1-stabilization/): Kaito S, Aoyama K, Oshima M, Tsuchiya A, Miyota M, Yamashita M, Koide S, Nakajima-Takagi Y, Kozuka-Hata H, Oyama M, Yogo T, Yabushita T, Ito R, Ueno M, Hirao A, Tohyama K, Li C, Kawabata KC, Yamaguchi K, Furukawa Y, Kosako H, Yoshimi A, Goyama S, Nannya Y, Ogawa S, Agger K, Helin K, Yamazaki S, […]
- [M2 macrophage-derived TGF-β induces age-associated loss of adipogenesis through progenitor cell senescence. ](https://dcr-imsut.com/index.php/2024/06/20/m2-macrophage-derived-tgf-%ce%b2-induces-age-associated-loss-of-adipogenesis-through-progenitor-cell-senescence/): Zeng X, Wang TW, Yamaguchi K, Hatakeyama S, Yamazaki S, Shimizu E, Imoto S, Furukawa Y, Johmura Y, Nakanishi M. Mol Metab. 2024 Jun;84:101943. doi: 10.1016/j.molmet.2024.101943. Epub 2024 Apr 23.PMID: 38657734
- [Heart failure promotes multimorbidity through innate immune memory. ](https://dcr-imsut.com/index.php/2024/05/24/heart-failure-promotes-multimorbidity-through-innate-immune-memory/): Nakayama Y, Fujiu K, Oshima T, Matsuda J, Sugita J, Matsubara TJ, Liu Y, Goto K, Kani K, Uchida R, Takeda N, Morita H, Xiao Y, Hayashi M, Maru Y, Hasumi E, Kojima T, Ishiguro S, Kijima Y, Yachie N, Yamazaki S, Yamamoto R, Kudo F, Nakanishi M, Iwama A, Fujiki R, Kaneda A, Ohara O, […]
- [Age-related changes in the hematopoietic stem cell pool revealed via quantifying the balance of symmetric and asymmetric divisions](https://dcr-imsut.com/index.php/2024/04/08/age-related-changes-in-the-hematopoietic-stem-cell-pool-revealed-via-quantifying-the-balance-of-symmetric-and-asymmetric-divisions/): Kawahigashi T, Iwanami S, Takahashi M, Bhadury J, Iwami S, Yamazaki S. PLoS One. 2024 Jan 29;19(1):e0292575. doi: 10.1371/journal.pone.0292575. eCollection 2024.PMID: 38285676 
- [Purging myeloma cell contaminants and simultaneous expansion of peripheral blood-mobilized stem cells](https://dcr-imsut.com/index.php/2024/03/25/purging-myeloma-cell-contaminants-and-simultaneous-expansion-of-peripheral-blood-mobilized-stem-cells/): Ishitsuka K, Nishikii H, Kimura T, Sugiyama-Finnis A, Yamazaki S. Exp Hematol. 2024 Mar;131:104138. doi: 10.1016/j.exphem.2023.104138. Epub 2023 Dec 25.PMID: 38151170 
- [New Review Published!](https://dcr-imsut.com/index.php/2024/03/21/new-paper-published-2/): Dr. Becker’s review has been published in the current issue of Experimental Hematology.
- [New paper published!](https://dcr-imsut.com/index.php/2024/03/12/new-paper-published-3/): Dr. Yamazaki’s paper was published in Stem Cell Reports.
- [Rejuvenated iPSC-derived GD2-directed CART Cells Harbor Robust CytotoxicityAgainst Small Cell Lung Cancer](https://dcr-imsut.com/index.php/2024/03/11/rejuvenated-ipsc-derived-gd2-directed-cart-cells-harbor-robust-cytotoxicityagainst-small-cell-lung-cancer/): Kinoshita S, Ishii M, Ando J, Kimura T, Yamaguchi T, Harada S, Takahashi F, Nakashima K, Nakazawa Y, Yamazaki S, Ohshima K, Takahashi K, Nakauchi H, Ando M.Cancer Res Commun. 2024 Mar 11;4(3):723-737. doi: 10.1158/2767-9764.CRC-23-0259. PMID: 38380966; PMCID: PMC10926899.
- [Lab Launch Event held](https://dcr-imsut.com/index.php/2024/03/01/lab-launch-event-held/): We officially started regular operations here at IMSUT! To kick things off, we held an inaugural barbecue party with all lab members. Check out our pictures page to see how it turned out.
- [New Review Published!](https://dcr-imsut.com/index.php/2024/03/01/new-review-published/): Dr. Sakurai’s review has been published in the current issue of Cancer Science.
- [Activated mesenchymal stem/stromal cells promote myeloid cell differentiationvia CCL2/CCR2 signaling](https://dcr-imsut.com/index.php/2024/02/29/activated-mesenchymal-stem-stromal-cells-promote-myeloid-cell-differentiationvia-ccl2-ccr2-signaling/): Yamazaki S, Mabuchi Y, Kimura T, Suto EG, Hisamatsu D, Naraoka Y, Kondo A, Azuma Y, Kikuchi R, Nishikii H, Morishita S, Araki M, Komatsu N, Akazawa C. Stem Cell Reports. 2024 Mar 12;19(3):414-425. doi:10.1016/j.stemcr.2024.02.002. Epub 2024 Feb 29. PMID: 38428413; PMCID: PMC10937152.
- [A novel Kit mutant rat enables hematopoietic stem cell engraftment without irradiation](https://dcr-imsut.com/index.php/2024/02/06/a-novel-kit-mutant-rat-enables-hematopoietic-stem-cell-engraftment-without-irradiation/): Iida R, Ishida S, Wang J, Hattori K, Yoshimi K, Yamazaki S, Mashimo T.Iida R, Ishida S, Wang J, Hattori K, Yoshimi K, Yamazaki S, Mashimo T. Exp Hematol. 2024 Apr;132:104174. doi: 10.1016/j.exphem.2024.104174. Epub 2024 Feb 6.PMID: 38331018
- [New paper published!](https://dcr-imsut.com/index.php/2024/01/29/new-paper-published-4/): Dr. Kawahigashi’s paper was published in PLOS ONE.
- [Understanding genetic heterogeneity in gene-edited hematopoietic stem cell products](https://dcr-imsut.com/index.php/2024/01/29/understanding-genetic-heterogeneity-in-gene-edited-hematopoietic-stem-cell-products/): Becker HJ, Yamazaki S. Exp Hematol. 2024 Jan;129:104133. doi: 10.1016/j.exphem.2023.11.007. Epub 2023 Nov 29.PMID: 38036097
- [Ex vivo expansion of human hematopoietic stem cells and clinical applications](https://dcr-imsut.com/index.php/2024/01/14/ex-vivo-expansion-of-human-hematopoietic-stem-cells-and-clinical-applications/): Sakurai M, Ishitsuka K, Becker HJ, Yamazaki S. Cancer Sci. 2024 Mar;115(3):698-705. doi: 10.1111/cas.16066. Epub 2024 Jan 14.PMID: 38221718 Free PMC article. 
- [2023](https://dcr-imsut.com/index.php/2023/12/31/2023/)
- [Hyperactive Natural Killer cells in Rag2 knockout mice inhibit the development of acute myeloid leukemia](https://dcr-imsut.com/index.php/2023/12/21/hyperactive-natural-killer-cells-in-rag2-knockout-mice-inhibit-the-development-of-acute-myeloid-leukemia/): Sugimoto E, Li J, Hayashi Y, Iida K, Asada S, Fukushima T, Tamura M, Shikata S, Zhang W, Yamamoto K, Kawabata KC, Kawase T, Saito T, Yoshida T, Yamazaki S, Kaito Y, Imai Y, Denda T, Ota Y, Fukuyama T, Tanaka Y, Enomoto Y, Kitamura T, Goyama S. Commun Biol. 2023 Dec 21;6(1):1294. doi: 10.1038/s42003-023-05606-3.PMID: 38129572 
- [LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits](https://dcr-imsut.com/index.php/2023/07/20/lonrf2-is-a-protein-quality-control-ubiquitin-ligase-whose-deficiency-causes-late-onset-neurological-deficits/): Li D, Johmura Y, Morimoto S, Doi M, Nakanishi K, Ozawa M, Tsunekawa Y, Inoue-Yamauchi A, Naruse H, Matsukawa T, Takeshita Y, Suzuki N, Aoki M, Nishiyama A, Zeng X, Konishi C, Suzuki N, Nishiyama A, Harris AS, Morita M, Yamaguchi K, Furukawa Y, Nakai K, Tsuji S, Yamazaki S, Yamanashi Y, Shimada S, Okada T, […]
- [Controlling genetic heterogeneity in gene-edited hematopoietic stem cells by single-cell expansion](https://dcr-imsut.com/index.php/2023/06/28/controlling-genetic-heterogeneity-in-gene-edited-hematopoietic-stem-cells-by-single-cell-expansion/): Becker HJ, Ishida R, Wilkinson AC, Kimura T, Lee MSJ, Coban C, Ota Y, Tanaka Y, Roskamp M, Sano T, Tojo A, Kent DG, Yamazaki S. Cell Stem Cell. 2023 Jul 6;30(7):987-1000.e8. doi: 10.1016/j.stem.2023.06.002. Epub 2023 Jun 28.PMID: 37385251
- [New Paper published!](https://dcr-imsut.com/index.php/2023/06/01/new-paper-published/): Dr. Becker’s paper has been published in the current issue of Cell Stem Cell .
- [Chemically defined cytokine-free expansion of human haematopoietic stem cells](https://dcr-imsut.com/index.php/2023/02/22/chemically-defined-cytokine-free-expansion-of-human-haematopoietic-stem-cells/): Sakurai M, Ishitsuka K, Ito R, Wilkinson AC, Kimura T, Mizutani E, Nishikii H, Sudo K, Becker HJ, Takemoto H, Sano T, Kataoka K, Takahashi S, Nakamura Y, Kent DG, Iwama A, Chiba S, Okamoto S, Nakauchi H, Yamazaki S.   Nature. 2023 Mar;615(7950):127-133. doi: 10.1038/s41586-023-05739-9. Epub 2023 Feb 22.PMID: 36813966
- [2022](https://dcr-imsut.com/index.php/2022/12/31/2022/)
- [[Development of low-cost ex vivo hematopoietic stem cell expansion]](https://dcr-imsut.com/index.php/2022/11/10/development-of-low-cost-ex-vivo-hematopoietic-stem-cell-expansion/): Kimura T, Yamazaki S.Rinsho Ketsueki. 2022;63(10):1422-1429. doi: 10.11406/rinketsu.63.1422.PMID: 36351651 Japanese.
- [Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes.](https://dcr-imsut.com/index.php/2022/11/02/blocking-pd-l1-pd-1-improves-senescence-surveillance-and-ageing-phenotypes/): Wang TW, Johmura Y, Suzuki N, Omori S, Migita T, Yamaguchi K, Hatakeyama S, Yamazaki S, Shimizu E, Imoto S, Furukawa Y, Yoshimura A, Nakanishi M.   Nature. 2022 Nov;611(7935):358-364. doi: 10.1038/s41586-022-05388-4. Epub 2022 Nov 2.PMID: 36323784
- [Identification and characterization of in vitro expanded hematopoietic stem cells](https://dcr-imsut.com/index.php/2022/08/16/identification-and-characterization-of-in-vitro-expanded-hematopoietic-stem-cells/): Che JLC, Bode D, Kucinski I, Cull AH, Bain F, Becker HJ, Jassinskaja M, Barile M, Boyd G, Belmonte M, Zeng AGX, Igarashi KJ, Rubio-Lara J, Shepherd MS, Clay A, Dick JE, Wilkinson AC, Nakauchi H, Yamazaki S, Göttgens B, Kent DG. EMBO Rep. 2022 Aug 16:e55502. doi: 10.15252/embr.202255502. PMID: 35971894
- [Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells](https://dcr-imsut.com/index.php/2022/05/16/epigenetic-traits-inscribed-in-chromatin-accessibility-in-aged-hematopoietic-stem-cells/): Itokawa N, Oshima M, Koide S, Takayama N, Kuribayashi W, Nakajima-Takagi Y, Aoyama K, Yamazaki S, Yamaguchi K, Furukawa Y, Eto K, Iwama A.   Nat Commun. 2022 May 16;13(1):2691. doi: 10.1038/s41467-022-30440-2.PMID: 35577813 
- [Hematopoietic progenitor cells specifically induce a unique immune response in dental pulp under conditions of systemic inflammation](https://dcr-imsut.com/index.php/2022/02/05/hematopoietic-progenitor-cells-specifically-induce-a-unique-immune-response-in-dental-pulp-under-conditions-of-systemic-inflammation/): Osaki J, Yamazaki S, Hikita A, Hoshi K. Heliyon. 2022 Feb 5;8(2):e08904. doi: 10.1016/j.heliyon.2022.e08904. eCollection 2022 Feb.PMID: 35198771 
- [Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma](https://dcr-imsut.com/index.php/2022/02/02/dual-antigen-targeted-ipsc-derived-chimeric-antigen-receptor-t-cell-therapy-for-refractory-lymphoma/): Harada S, Ando M, Ando J, Ishii M, Yamaguchi T, Yamazaki S, Toyota T, Ohara K, Ohtaka M, Nakanishi M, Shin C, Ota Y, Nakashima K, Ohshima K, Imai C, Nakazawa Y, Nakauchi H, Komatsu N Mol Ther. 2022 Feb 2;30(2):534-549. doi: 10.1016/j.ymthe.2021.10.006. Epub 2021 Oct 8.PMID: 34628050
- [Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma. ](https://dcr-imsut.com/index.php/2022/02/02/dual-antigen-targeted-ipsc-derived-chimeric-antigen-receptor-t-cell-therapy-for-refractory-lymphoma-2/): Harada S, Ando M, Ando J, Ishii M, Yamaguchi T, Yamazaki S, Toyota T, Ohara K, Ohtaka M, Nakanishi M, Shin C, Ota Y, Nakashima K, Ohshima K, Imai C, Nakazawa Y, Nakauchi H, Komatsu N. Mol Ther. 2022 Feb 2;30(2):534-549. doi: 10.1016/j.ymthe.2021.10.006. Epub 2021 Oct 8.PMID: 34628050
- [2021](https://dcr-imsut.com/index.php/2021/12/31/2021/)
- [Immunohistological score of transcription factor 21 had a positive correlation with its urinary excretion and proteinuria in immunoglobulin A nephropathy.](https://dcr-imsut.com/index.php/2021/10/17/immunohistological-score-of-transcription-factor-21-had-a-positive-correlation-with-its-urinary-excretion-and-proteinuria-in-immunoglobulin-a-nephropathy/): Takahashi-Kobayashi M, Usui J, Yaguchi M, Yamazaki S, Kawamura T, Kaneko S, Seshan SV, Yamagata K. Histol Histopathol. 2021 Oct;36(10):1093-1098. doi: 10.14670/HH-18-367. Epub 2021 Jul 29.PMID: 34323285
- [Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo. ](https://dcr-imsut.com/index.php/2021/10/17/polyvinyl-alcohol-hydrolysis-rate-and-molecular-weight-influence-human-and-murine-hsc-activity-ex-vivo/): Sudo K, Yamazaki S, Wilkinson AC, Nakauchi H, Nakamura Y.  Stem Cell Res. 2021 Oct;56:102531. doi: 10.1016/j.scr.2021.102531. Epub 2021 Sep 3.PMID: 34509158 
- [iPSC-derived neoantigen-specific cytotoxic T-lymphocyte therapy for Ewing sarcoma. ](https://dcr-imsut.com/index.php/2021/10/09/ipsc-derived-neoantigen-specific-cytotoxic-t-lymphocyte-therapy-for-ewing-sarcoma/): Ishii M, Ando J, Yamazaki S, Toyota T, Ohara K, Furukawa Y, Suehara Y, Nakanishi M, Nakashima K, Ohshima K, Nakauchi H, Ando M. Cancer Immunol Res. 2021 Oct;9(10):1175-1186. doi: 10.1158/2326-6066.CIR-21-0193. Epub 2021 Aug 12.PMID: 34385178
- [Non-conditioned bone marrow chimeric mouse generation using culture-based enrichment of hematopoietic stem and progenitor cells.](https://dcr-imsut.com/index.php/2021/06/11/non-conditioned-bone-marrow-chimeric-mouse-generation-using-culture-based-enrichment-of-hematopoietic-stem-and-progenitor-cells/): Ochi K, Morita M, Wilkinson AC, Iwama A, Yamazaki S.  Nat Commun. 2021 Jun 11;12(1):3568. doi: 10.1038/s41467-021-23763-z.PMID: 34117255 
- [Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche. ](https://dcr-imsut.com/index.php/2021/03/01/limited-rejuvenation-of-aged-hematopoietic-stem-cells-in-young-bone-marrow-niche/): Kuribayashi W, Oshima M, Itokawa N, Koide S, Nakajima-Takagi Y, Yamashita M, Yamazaki S, Rahmutulla B, Miura F, Ito T, Kaneda A, Iwama A. J Exp Med. 2021 Mar 1;218(3):e20192283. doi: 10.1084/jem.20192283.PMID: 33231616
- [DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes.](https://dcr-imsut.com/index.php/2021/01/26/dhodh-inhibition-synergizes-with-dna-demethylating-agents-in-the-treatment-of-myelodysplastic-syndromes/): Kayamori K, Nagai Y, Zhong C, Kaito S, Shinoda D, Koide S, Kuribayashi W, Oshima M, Nakajima-Takagi Y, Yamashita M, Mimura N, Becker HJ, Izawa K, Yamazaki S, Iwano S, Miyawaki A, Ito R, Tohyama K, Lennox W, Sheedy J, Weetall M, Sakaida E, Yokote K, Iwama A.  Blood Adv. 2021 Jan 26;5(2):438-450. doi: 10.1182/bloodadvances.2020001461.PMID: 33496740 
- [2020](https://dcr-imsut.com/index.php/2020/12/31/2020/)
- [Efficacy of the Novel Tubulin Polymerization Inhibitor PTC-028 for Myelodysplastic Syndrome ](https://dcr-imsut.com/index.php/2020/12/17/efficacy-of-the-novel-tubulin-polymerization-inhibitor-ptc-028-for-myelodysplastic-syndrome/): Zhong C, Kayamori K, Koide S, Shinoda D, Oshima M, Nakajima-Takagi Y, Nagai Y, Mimura N, Sakaida E, Yamazaki S, Iwano S, Miyawaki A, Ito R, Tohyama K, Yamaguchi K, Furukawa Y, Lennox W, Sheedy J, Weetall M, Iwama A.  Cancer Sci. 2020 Dec;111(12):4336-4347. doi: 10.1111/cas.14684. Epub 2020 Nov 2.PMID: 33037737 
- [The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages.](https://dcr-imsut.com/index.php/2020/11/23/the-impact-of-cell-maturation-and-tissue-microenvironments-on-the-expression-of-endosomal-toll-like-receptors-in-monocytes-and-macrophages/): Sato R, Reuter T, Hiranuma R, Shibata T, Fukui R, Motoi Y, Murakami Y, Tsukamoto H, Yamazaki S, Liu K, Saitoh SI, Latz E, Miyake K.  Int Immunol. 2020 Nov 23;32(12):785-798. doi: 10.1093/intimm/dxaa055.PMID: 32840578
- [Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo.](https://dcr-imsut.com/index.php/2020/11/03/generation-of-a-p16-reporter-mouse-and-its-use-to-characterize-and-target-p16high-cells-in-vivo/): Omori S, Wang TW, Johmura Y, Kanai T, Nakano Y, Kido T, Susaki EA, Nakajima T, Shichino S, Ueha S, Ozawa M, Yokote K, Kumamoto S, Nishiyama A, Sakamoto T, Yamaguchi K, Hatakeyama S, Shimizu E, Katayama K, Yamada Y, Yamazaki S, Iwasaki K, Miyoshi C, Funato H, Yanagisawa M, Ueno H, Imoto S, Furukawa Y, Yoshida […]
- [Activated HoxB4-induced Hematopoietic Stem Cells from Murine Pluripotent Stem Cells via Long-Term Programming.](https://dcr-imsut.com/index.php/2020/09/17/activated-hoxb4-induced-hematopoietic-stem-cells-from-murine-pluripotent-stem-cells-via-long-term-programming/): Izawa K, Yamazaki S, Becker HJ, Bhadury J, Kakegawa T, Sakaguchi M, Tojo A.  Exp Hematol. 2020 Sep;89:68-79.e7. doi: 10.1016/j.exphem.2020.08.003. Epub 2020 Aug 12.PMID: 32795499 
- [Transcription factor 21 expression in injured podocytes of glomerular diseases. ](https://dcr-imsut.com/index.php/2020/07/13/transcription-factor-21-expression-in-injured-podocytes-of-glomerular-diseases/): Usui J, Yaguchi M, Yamazaki S, Takahashi-Kobayashi M, Kawamura T, Kaneko S, Seshan SV, Ronco P, Yamagata K. Sci Rep. 2020 Jul 13;10(1):11516. doi: 10.1038/s41598-020-68422-3.PMID: 32661376
- [In vivo expansion of functional human hematopoietic stem progenitor cells by butyzamide. ](https://dcr-imsut.com/index.php/2020/05/17/in-vivo-expansion-of-functional-human-hematopoietic-stem-progenitor-cells-by-butyzamide/): Sakurai M, Takemoto H, Mori T, Okamoto S, Yamazaki S.  Int J Hematol. 2020 May;111(5):739-741. doi: 10.1007/s12185-020-02849-2. Epub 2020 Mar 12.PMID: 32162097
- [Long-term eradication of extranodal NK/T cell lymphoma, nasal type, by induced pluripotent stem cell-derived Epstein-Barr virus-specific rejuvenated T cells in vivo.](https://dcr-imsut.com/index.php/2020/03/17/long-term-eradication-of-extranodal-nk-t-cell-lymphoma-nasal-type-by-induced-pluripotent-stem-cell-derived-epstein-barr-virus-specific-rejuvenated-t-cells-in-vivo-2/): Ando M, Ando J, Yamazaki S, Ishii M, Sakiyama Y, Harada S, Honda T, Yamaguchi T, Nojima M, Ohshima K, Nakauchi H, Komatsu N.  Haematologica. 2020 Mar;105(3):796-807. doi: 10.3324/haematol.2019.223511. Epub 2019 Jul 11.PMID: 31296577 
- [Long-term ex vivo expansion of mouse hematopoietic stem cells.](https://dcr-imsut.com/index.php/2020/02/15/long-term-ex-vivo-expansion-of-mouse-hematopoietic-stem-cells/): Wilkinson AC, Ishida R, Nakauchi H, Yamazaki S. Nat Protoc. 2020 Feb;15(2):628-648. doi: 10.1038/s41596-019-0263-2. Epub 2020 Jan 8.PMID: 31915389 
- [2019](https://dcr-imsut.com/index.php/2019/12/31/2019/)
- [Use of polyvinyl alcohol for chimeric antigen receptor T-cell expansion.](https://dcr-imsut.com/index.php/2019/12/17/use-of-polyvinyl-alcohol-for-chimeric-antigen-receptor-t-cell-expansion/): Nishimura T, Hsu I, Martinez-Krams DC, Nakauchi Y, Majeti R, Yamazaki S, Nakauchi H, Wilkinson AC. Exp Hematol. 2019 Dec;80:16-20. doi: 10.1016/j.exphem.2019.11.007. Epub 2019 Dec 23.PMID:31874780
- [Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma.](https://dcr-imsut.com/index.php/2019/12/17/akt-inhibition-synergizes-with-polycomb-repressive-complex-2-inhibition-in-the-treatment-of-multiple-myeloma/): Rizk M, Rizq O, Oshima M, Nakajima-Takagi Y, Koide S, Saraya A, Isshiki Y, Chiba T, Yamazaki S, Ma A, Jin J, Iwama A, Mimura N.  Cancer Sci. 2019 Dec;110(12):3695-3707. 
- [Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia.](https://dcr-imsut.com/index.php/2019/10/25/antitumor-immunity-augments-the-therapeutic-effects-of-p53-activation-on-acute-myeloid-leukemia/): Hayashi Y, Goyama S, Liu X, Tamura M, Asada S, Tanaka Y, Fukuyama T, Wunderlich M, O’Brien E, Mizukawa B, Yamazaki S, Matsumoto A, Yamasaki S, Shibata T, Matsuda K, Sashida G, Takizawa H, Kitamura T.  Nat Commun. 2019 Oct 25;10(1):4869.
- [Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche.](https://dcr-imsut.com/index.php/2019/08/17/bmi1-restricts-the-adipogenic-differentiation-of-bone-marrow-stromal-cells-to-maintain-the-integrity-of-the-hematopoietic-stem-cell-niche/): Kato Y, Hou LB, Miyagi S, Nitta E, Aoyama K, Shinoda D, Yamazaki S, Kuribayashi W, Isshiki Y, Koide S, Si S, Saraya A, Matsuzaki Y, van Lohuizen M, Iwama A. Exp Hematol. 2019 Aug;76:24-37. Epub 2019 Aug 11.
- [Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned 　transplantation.](https://dcr-imsut.com/index.php/2019/07/17/long-term-ex-vivo-haematopoietic-stem-cell-expansion-allows-nonconditioned-%e3%80%80transplantation/): Wilkinson AC, Ishida R, Kikuchi M, Sudo K, Morita M, Crisostomo RV, Yamamoto R, Loh KM, Nakamura Y, Watanabe M, Nakauchi H, Yamazaki S.  Nature. 2019. doi: 10.1038/s41586-019-1244. 
- [Long-term eradication of extranodal NK/T cell lymphoma, nasal type, by induced pluripotent stem cell-derived Epstein-Barr virus-specific rejuvenated T cells in vivo.](https://dcr-imsut.com/index.php/2019/07/11/long-term-eradication-of-extranodal-nk-t-cell-lymphoma-nasal-type-by-induced-pluripotent-stem-cell-derived-epstein-barr-virus-specific-rejuvenated-t-cells-in-vivo/): Ando M, Ando J, Yamazaki S, Ishii M, Sakiyama Y, Harada S, Honda T, Yamaguchi T, Nojima M, Ohshima K, Nakauchi H, Komatsu N. Haematologica. 2019 Jul 11. pii: haematol.2019.223511.2019.223511
- [Mesenchymal-Epithelial Interactome Analysis Reveals Essential Factors Required for Fibroblast-Free Alveolosphere Formation.](https://dcr-imsut.com/index.php/2019/01/25/mesenchymal-epithelial-interactome-analysis-reveals-essential-factors-required-for-fibroblast-free-alveolosphere-formation/): Shiraishi K, Shichino S, Ueha S, Nakajima T, Hashimoto S, Yamazaki S, Matsushima K. iScience. 2019 Jan 25;11:318-333.
- [2018](https://dcr-imsut.com/index.php/2018/12/31/2018/)
- [Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation. ](https://dcr-imsut.com/index.php/2018/10/09/generation-of-vascular-endothelial-cells-and-hematopoietic-cells-by-blastocyst-complementation/): Hamanaka S, Umino A, Sato H, Hayama T, Yanagida A, Mizuno N, Kobayashi T, Kasai M, Suchy FP, Yamazaki S, Masaki H, Yamaguchi T, Nakauchi H. Stem Cell Reports. 2018 Oct 9;11(4):988-997.
- [Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.](https://dcr-imsut.com/index.php/2018/07/16/mutant-asxl1-cooperates-with-bap1-to-promote-myeloid-leukaemogenesis/): Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T. Nat Commun. 2018 Jul 16;9(1):2733. 
- [Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress. ](https://dcr-imsut.com/index.php/2018/05/03/spred1-safeguards-hematopoietic-homeostasis-against-diet-induced-systemic-stress/): Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi H, Hirao A.  Cell Stem Cell. 2018 May 3;22(5):713-725.e8. 
- [Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells.](https://dcr-imsut.com/index.php/2018/04/27/hematopoietic-insults-damage-bone-marrow-niche-by-activating-p53-in-vascular-endothelial-cells/): Si S, Nakajima-Takagi Y, Iga T, Tsuji M, Hou L, Oshima M, Koide S, Saraya A, Yamazaki S, Takubo K, Kubota Y, Minamino T, Iwama A.  Exp Hematol. 2018 Apr 27. pii: S0301-472X(18)30213-3.
- [Branched-chain amino acid depletion conditions bone marrow for hematopoietic stem cell transplantation avoiding amino acid imbalance-associated toxicity. ](https://dcr-imsut.com/index.php/2018/04/26/branched-chain-amino-acid-depletion-conditions-bone-marrow-for-hematopoietic-stem-cell-transplantation-avoiding-amino-acid-imbalance-associated-toxicity/): Wilkinson AC, Morita M, Nakauchi H, Yamazaki S.  Exp Hematol. 2018 Apr 26. S0301-472 (18)30173-5. 
- [Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice. ](https://dcr-imsut.com/index.php/2018/02/08/physiological-srsf2-p95h-expression-causes-impaired-hematopoietic-stem-cell-functions-and-aberrant-rna-splicing-in-mice/): Kon A, Yamazaki S, Nannya Y, Kataoka K, Ota Y, Nakagawa MM, Yoshida K, Shiozawa Y, Morita M, Yoshizato T, Sanada M, Nakayama M, Koseki H, Nakauchi H, Ogawa S.  Blood. 2018 Feb 8;131(6):621-635. 
- [2017](https://dcr-imsut.com/index.php/2017/12/26/2017/)
- [In Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma. ](https://dcr-imsut.com/index.php/2017/10/10/in-vivo-generation-of-engraftable-murine-hematopoietic-stem-cells-by-gfi1b-c-fos-and-gata2-overexpression-within-teratoma/): Tsukada M, Ota Y, Wilkinson AC, Becker HJ, Osato M, Nakauchi H, Yamazaki S. Stem Cell Reports. 2017 Oct 10;9(4):1024-1033. 
- [An All-Recombinant Protein-Based Culture System Specifically Identifies Hematopoietic Stem Cell Maintenance Factors. ](https://dcr-imsut.com/index.php/2017/03/14/an-all-recombinant-protein-based-culture-system-specifically-identifies-hematopoietic-stem-cell-maintenance-factors/): Ieyasu A, Ishida R, Kimura T, Morita M, Wilkinson AC, Sudo K, Nishimura T, Ohehara J, Tajima Y, Lai CY, Otsu M, Nakamura Y, Ema H, Nakauchi H,Yamazaki S.  Stem Cell Reports. 2017 Mar 14 ;8(3):500-508.
- [Continuous cell supply from Krt7-expressing hematopoietic stem cells during native hematopoiesis revealed by targeted in vivo gene transfer method.](https://dcr-imsut.com/index.php/2017/01/18/continuous-cell-supply-from-krt7-expressing-hematopoietic-stem-cells-during-native-hematopoiesis-revealed-by-targeted-in-vivo-gene-transfer-method/): Tajima Y, Ito K, Umino A, Wilkinson AC, Nakauchi H, Yamazaki S. Sci Rep. 2017 Jan 18 ;7:40684.
- [Before 2016](https://dcr-imsut.com/index.php/2016/12/31/before-2016/)
- [Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation.](https://dcr-imsut.com/index.php/2016/10/20/depleting-dietary-valine-permits-nonmyeloablative-mouse-hematopoietic-stem-cell-transplantation/): Taya Y, Ota Y, Wilkinson AC, Kanazawa A, Watarai H, Kasai M, Nakauchi H and Yamazaki S. Science. Oct 20, 2016 354(6316):1152-1155.
- [Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenyous perivascular niche. ](https://dcr-imsut.com/index.php/2016/02/11/hoxb5-marks-long-term-haematopoietic-stem-cells-and-reveals-a-homogenyous-perivascular-niche/): Chen JY, Miyanishi M, Wang SK, Yamazaki S, Shnha R, Kao KS, Seita J, Sahoo D, Nakauchi H, Weissman IL. Nature. 2016 Feb 11;530(7589):223-7.
- [A Safeguard System for Induced Pluripotent Stem Cell Derived Rejuvenated T Cell Therapy.](https://dcr-imsut.com/index.php/2015/10/13/a-safeguard-system-for-induced-pluripotent-stem-cell-derived-rejuvenated-t-cell-therapy/): Ando M, Nishimura T, Yamazaki S, Yamaguchi T, Kawana-Tachikawa A, Hayama T, Nakauchi Y, Ando J, Ota Y, Takahashi S, Nishimura K, Ohtaka M, Nakanishi M, Miles JJ, Burrows SR, Brenner MK, Nakauchi H.  Stem Cell Reports. 2015 Oct 13;5(4): 597-608.
- [Reactive oxygen species in hematopoietic stem cells affect culture outcome under inflammatory conditions. ](https://dcr-imsut.com/index.php/2015/07/17/reactive-oxygen-species-in-hematopoietic-stem-cells-affect-culture-outcome-under-inflammatory-conditions/): Ishida T, Yamazaki S, Nakauchi H, Higashihara M, Otsu M.  Open Journal of Hematology. 2015;6:6-7.
- [Effective treatment against severe Graft-versus-Host Disease with allele-specific anti-HLA monoclonal antibody in a humanized-mouse model. ](https://dcr-imsut.com/index.php/2015/02/17/effective-treatment-against-severe-graft-versus-host-disease-with-allele-specific-anti-hla-monoclonal-antibody-in-a-humanized-mouse-model/): Nakauchi Y, Yamazaki S, Napier C S, Usui J, Ota Y, Takahashi S, Watanabe N, Nakauchi H.  Exp Hematol. 2015 Feb;43(2):79-88.
- [Impaired hematopoietic differentiation of RUNX1 mutated induced pluripotent stem cells derived from FPD/AML patients.](https://dcr-imsut.com/index.php/2014/12/28/impaired-hematopoietic-differentiation-of-runx1-mutated-induced-pluripotent-stem-cells-derived-from-fpd-aml-patients/): Sakurai M, Kunimoto H, Watanabe N, Fukuchi Y, Yuasa S, Yamazaki S, Nishimura T, Sadahira K, Fukuda K, Okano H, Nakauchi H, Morita Y, Matsumura I, Kudo K, Ito E, Ebihara Y, Tsuji K, Harada Y, Harada H, Okamoto S, Nakajima H. Leukemia. 2014 Dec:28(12):2344-54.
- [Generation of recombination activating gene-1-deficient neonatal piglets: a model of T and B cell deficient severe combined immune deficiency.](https://dcr-imsut.com/index.php/2014/12/01/generation-of-recombination-activating-gene-1-deficient-neonatal-piglets-a-model-of-t-and-b-cell-deficient-severe-combined-immune-deficiency/): Ito T, Sendai Y, Yamazaki S, Seki-Soma M, Hirose K, Watanabe M, Fukawa K, Nakauchi H.  PLoS One. 2014 Dec 1;9(12):e113833.
- [A melanocyte-melanoma precursor niche in sweat glands of volar skin.](https://dcr-imsut.com/index.php/2014/11/17/a-melanocyte-melanoma-precursor-niche-in-sweat-glands-of-volar-skin/): Okamoto N, Aoto T, Uhara H, Yamazaki S, Akutsu H, Umezawa A, Nakauchi H, Miyachi Y, Saida T, Nishimura EK. Pigment Cell Melanoma. 2014 Nov;27(6):1039-50.

## Pages

- [2025](https://dcr-imsut.com/index.php/2025-2/)
- [Contact](https://dcr-imsut.com/index.php/contact/): Contact information Division of Cell Regulation,Center for Experimental Medicine and Systems Biology The Institute of Medical Science, University of Tokyo4-6-1 Shirokanedai, Minato-kuTokyo 108-8639, JAPAN cellregulation0901[at]gmail.com Recruiting students : If you are interested in our research, please contact us at any time! 大学院生募集について：私たちの研究に興味をお持ちの方はお気軽にご連絡ください！
- [The Lab](https://dcr-imsut.com/index.php/the-lab/): Professor Satoshi YAMAZAKI Associate Professor Yosuke TANAKA Assistant Professor Takao YOGO Project Assistant Professor Hyojung JEON Project Assistant Professor Yuko KAWANO Researcher Kiyoko IZAWA Researcher Takaharu KIMURA Researcher Tsuyoshi FUKUSHIMA Researcher Mayumi TAKAHASHI Co-Researcher Tsubasa SANO Lab Technician Reiko ISHIDA Lab Technician Misako KIKUCHI Administrative Staff Asami MIYAMOTO Graduate Student (PhD) Ayano FINNIS Graduate Student […]
- [Publications](https://dcr-imsut.com/index.php/publications/): Publications
- [Research](https://dcr-imsut.com/index.php/projects/): regulatory mechanisms underlying self-renewal and differentiation of hematopoietic stem cells Our studies focus mainly on investigation of stem cell biology using the hematopoietic stem cell (HSC) as a research model. Recent identification of a variety of stem cell sources including embryonic and somatic (tissue-specific) stem cells has brought about substantial progress in the field of […]
- [Home](https://dcr-imsut.com/): From Basic to translational. Focusing on adult stem cells, our goal is to understand how cellular states are regulated and how to control these mechanisms to enable new therapeutic approaches. 基礎から応用へ 私たちの目標は、成人幹細胞に焦点を当て、細胞の状態がどのように制御されているかを理解し、それらのメカニズムを操作して新しい治療法の可能性を探ることです News


[comment]: # (Generated by Hostinger Tools Plugin)